NEST360 is an alliance of 20 organisations, 17 in Africa, with four African country governments: Kenya, Malawi, Nigeria, and Tanzania. NEST360 is supporting these governments to implement a health systems package for high-quality level-2 Small and Sick Newborn Care. Frontline clinicians, biomedical technicians, and quality improvement leaders form a learning network in more than 67 facilities across the four countries. Ethiopia will soon be joining the Alliance.